SIMILARLY LETHAL STRAINS OF EXTRAINTESTINAL PATHOGENIC ESCHERICHIA COLI TRIGGER MARKEDLY DIVERSE HOST RESPONSES IN A ZEBRAFISH MODEL OF SEPSIS

Similarly Lethal Strains of Extraintestinal Pathogenic Escherichia coli Trigger Markedly Diverse Host Responses in a Zebrafish Model of Sepsis

ABSTRACT In individuals with sepsis, the infecting microbes are commonly viewed as generic inducers of inflammation while the host background is considered the primary variable affecting disease progression and outcome.To study the effects of bacterial strain differences on the maladaptive immune responses that are induced during sepsis, we employe

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New Insights into the Physiology of the Propionate Producers Anaerotignum propionicum and Anaerotignum neopropionicum (Formerly Clostridium propionicum and Clostridium neopropionicum)

Propionate is an important platform chemical that is available through petrochemical synthesis.Bacterial propionate formation is considered an alternative, as bacteria can convert waste substrates into valuable products.In this regard, research primarily focused on propionibacteria due to high propionate titers achieved from different substrates.Wh

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Computation-based virtual screening for designing novel antimalarial drugs by targeting falcipain-III: A structure-based drug designing approach

Background & objectives: Cysteine proteases (falcipains), a papain-family of enzymes of Plasmodium falciparum, are responsible for haemoglobin degradation and thus necessary for its survival during asexual life cycle phase inside the human red blood cells while remaining non-functional for the human body.Therefore, these can act as potential target

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